BME Dissertation Defense: DoHyun Kim Dissertation Defense: DoHyun Kim2019-04-05T05:00:00Z10:00 amEPNEC Seminar Room B, Medical Campus<p rtenodeid="9"><strong>Title:  Approaches to Understanding the Function of Intrinsic Activity and its Relationship to Task-evoked Activity in the Human Brain </strong><br/></p><p rtenodeid="9"><strong>Abstract:<br/></strong>Traditionally neuroscience research has focused on characterizing the topography and patterns of brain activation evoked by specific cognitive or behavioral tasks to understand human brain functions. This activation-based paradigm treated underlying spontaneous brain activity, a.k.a. intrinsic activity, as noise hence irrelevant to cognitive or behavioral functions. This view, however, has been profoundly modified by the discovery that intrinsic activity is not random, but temporally correlated at rest in widely distributed spatiotemporal patterns, so called resting state networks (RSN). Studies of temporal correlation of spontaneous activity among brain regions, or functional connectivity (FC), have yielded important insights into the network organization of the human brain. However, the underlying fundamental relationship between intrinsic and task-evoked brain activity has remained unclear, becoming an increasingly important topic in neuroscience. An emerging view is that neural activity evoked by a task and the associated behavior is influenced and constrained by intrinsic activity.<br/></p><div>Additionally, intrinsic activity may be shaped in the course of development or adult life by neural activity evoked by a task through a Hebbian learning process. This thesis aims to reveal correspondences between intrinsic activity and task-evoked activity to better understand the nature and function of intrinsic brain activity. We measured in human visual cortex the blood oxygen level dependent (BOLD) signal with fMRI to analyze the multivoxel activity patterns and FC structures of intrinsic activity, and compare them to those evoked by natural and synthetic visual stimuli.<br/><br/></div><div>In chapter 1, we review previous evidence of an association between intrinsic and task-evoked activity across studies using different experimental methods. Two experimental strategies from the literature were adapted to our own experiments. First, from anesthetized animal studies of intrinsic activity in visual cortex, we set out to measure of macro-scale multi-voxel patterns of spontaneous activity fluctuations as they relate to visually driven patterns of activity (Chapters 2 and 4). Second, from inter-subject correlation studies of visual activity driven by natural stimuli, we adapted studies in Chapter 5.<br/><br/></div><div>In Chapter 2 to 4, we establish a multivariate-pattern analysis (MVPA) approach to evaluate patterns of intrinsic and task-evoked activity. The main idea is that patterns of activity induced by behaviorally relevant stimuli over long periods of time would be represented in spontaneous activity patterns within the same areas. To test the idea, in Chapter 2, we compare the overall degree of pattern similarities among frame-wise resting-state activity patterns and visual-stimulus evoked activity patterns for natural and synthetic (phase and position scrambled) object images during low-level detection task. We found that the variability, not mean, of pattern similarity was significantly higher for natural than synthetic stimuli in visual occipital regions that preferred particular stimulus categories. Chapter 3 extends the static categorical pattern similarity measure of Chapter 2 into a temporal correlation measure. We built pattern-based FC matrices in regions that preferred particular stimulus categories. These pattern-based FCs resemble that of resting-state FC of the same regions indicating that resting state patterns are related to category-specific stimulus-evoked multivoxel activity patterns. In Chapter 4, we repeat the analysis used in Chapter 2 with language stimuli. Language stimuli (alphabetic letters and English words) are interesting as they are learned through intensive training as kids learn to read. Therefore, they represent a non-natural category of stimuli that is however highly trained in literate individuals.<br/><br/></div><div>The visual stimuli used in Chapter 2 to 4 are designed specifically for a laboratory environment that does not correspond to realistic ecological environments. In Chapter 5, to overcome this limitation, we use the more naturalistic visual experience of movie-watching and compare the whole-brain FC network structure of movie-watching and of resting-state. We show the whole-brain FC structure evoked by movie-watching is partly constrained by the resting network structure.<br/></div><div><br/></div><div>In conclusion, we demonstrate a link between intrinsic activity and task-evoked activity in terms of multi-vertex activity patterns and FC network structures, supporting the idea of a closed-cycle relationship between task-evoked activity and intrinsic activity in human brain.<br/></div>Dr. Maurizio Corbetta
Women & Engineering Leadership Society Summit & Engineering Leadership Society Summit2019-04-06T05:00:00Z8:30 a.m.Innovation Hall
4220 Duncan Ave 
St. Louis, MO 63110<h3>​The goal of the Summit is to strengthen women engineers affiliated with Washington University by providing workshops and speakers centered around personal and professional development. The event will connect alumnae and students who can learn from one another and expand networks.<br/></h3><h4><a href="">More event details.</a><br/></h4><h4><a href="">RSVP by Thursday, March 28.</a><br/></h4><p><br/></p><p><span style="color: #555555; font-family: "libre baskerville", "times new roman", serif; font-size: 1.25em;">Keynote presentation:  Stories from a Career in Medical Technology</span><br/></p><div><img src="/Events/PublishingImages/Lorenz%20WE%20Summit%202019.jpg?RenditionID=7" class="ms-rtePosition-1" alt="" style="margin: 10px;"/>Christine Lorenz currently serves as chief operating officer at Cohesic Inc., a startup company in Calgary, Canada, focused on improving patient care improving data collection and analytics in cardiovascular diagnostics.  Prior to this, she held a variety of management roles in the healthcare businesses of Siemens over nearly 20 years, most recently as VP, Research and Clinical Collaborations in Siemens Molecular Imaging. She worked for Siemens in the UK, Germany and the US with a focus on R&D in the medical imaging field.  Lorenz has worked in both diagnostic imaging and image guided surgery.  Prior to her Siemens career, she was in academic medicine, first as an Assistant Professor of Radiology at Vanderbilt University and then as an Associate Professor of Medicine at Washington University in St. Louis as head of a lab conducting research in cardiac MRI.  She holds a BS in mechanical engineering from Washington University and was a Langsdorf Scholar. She was also one of the first Washington University students to participate in an exchange program with INSA, a university in Lyon, France.  </div><div><br/></div><div>Her MS in mechanical engineering and PhD in biomedical engineering were obtained at Vanderbilt University, and she later earned an MBA from the European School of Management and Technology in Berlin, Germany.  Lorenz believes strongly in the power of education and in Washington University’s mission and is a scholarship sponsor and a member of the National Council for the McKelvey School of Engineering.<br/></div><div><br/></div><div><span><hr/></span><br/></div><div><h4>8:30 a.m. — Breakfast<br/></h4><h4>9 a.m. — Welcome </h4><div>Emily Boyd, Teaching Professor, MEMS</div><div><br/></div><div>McKelvey School of Engineering Update</div><div>Aaron Bobick, Dean and James M. McKelvey Professor<br/></div><h4>9:40 a.m. — Breakout session #1:</h4><div><br/></div><div>“Career Paths are NOT a Straight Line”</div><div>Bayer US Crop Science </div><div><br/></div><div> “What It’s Really Like to be a Female Engineering Graduate Student”</div><div>McKelvey Engineering Graduate Students<br/></div><h4>10:50 a.m. — Breakout session #2:<br/></h4><div>“When Engineers Encounter the Community”</div><div>Heather Robinett, BS ‘95</div><div>Sandra Matteucci, Director & Senior Lecturer, Engineering Communications Center</div><div><br/></div><div>“How Remarkable Women Lead”</div><div>Leadership Society<br/></div><h4>Noon — Lunch<br/></h4><div>Introduction of speaker</div><div>Alexis Park, Class of 2019</div><div><br/></div><div>Presentation</div><div>“Stories from a Career in Technology”</div><div>Christine Lorenz, BS ‘86<br/></div><h4>1:15 p.m. — Reflection workshop<br/></h4><h4>1:45 p.m. — Closing remarks</h4><div>Claire Frey, DSc ‘95<br/></div><h4>2 p.m. — Cortex Innovation Community Tour</h4><div>
Brianna Tobias, Event Coordinator & Relationship Manager, CIC St. Louis</div><br/><br/></div>Julie Anderson: or 314-935-8730.
CBAC Seminar: Nathan Huebsch, PhD Seminar: Nathan Huebsch, PhD2019-04-15T05:00:00Z5:15 pmRoom 218, Whitaker Hall<p><strong>​Nathan Huebsch, PhD</strong><br/>Assistant Professor of Biomedical Engineering<br/>Washington University in St Louis<br/></p><p><a href="/Events/Documents/HUEBSCH_NathanFLYER.pdf" rtenodeid="2"><strong>Human iPSC-Based Engineered Micro-Tissues to Study Familial Cardiomyopathy</strong></a><br/></p>Gwen Nguyen
Engineering Honors Ceremony Honors Ceremony2019-04-17T05:00:00Z4 p.m.5:30 p.m.Whitaker Hall, Room 100<p>​Dean Aaron Bobick invites all to celebrate and recognize outstanding students, staff and faculty at this annual event.</p><p>If you have questions regarding<a href="/Events/Pages/awards-norm.aspx"> award eligibility or the nomination process</a>, please contact Tara Crites.<br/></p>Undergraduate Engineering Student Services: 314-935-6100
BME Seminar: Janice L. Robertson, PhD Seminar: Janice L. Robertson, PhD2019-04-18T05:00:00Z10:10 amRoom 012, Brauer Hall<p><strong>​</strong><a href="" rtenodeid="5"><strong>Janice L. Robertson, PhD</strong></a><br/>Assistant Professor<br/>Washington University in St Louis<br/></p><p><a href="/Events/Documents/Robertson,%20Janice%20Poster.pdf" rtenodeid="2"><strong>Driving Forces of Greasy Protein Association in Greasy Membranes</strong></a><br/></p><p rtenodeid="2"><b><em>Abstract:<br/></em></b>Membrane proteins are the molecular gatekeepers of biology.  They govern the passage of charged and polar species in and out of cells, thus enabling the storage of potential energy that fuels life.  Despite their overwhelming importance, we still do not understand the basic physical reasons why membrane proteins associate and assemble to form stable structures in the lipid bilayer.  For soluble proteins, the burial of hydrophobic groups away from aqueous interfaces is a major driving force, but membrane-embedded proteins cannot experience hydrophobic forces, as the lipid bilayer lacks water. A fundamental conundrum thus arises: how does a greasy protein surface find its greasy protein partner in the greasy lipid bilayer to fold faithfully into its native structure? In our lab, we measure the thermodynamics of membrane protein assembly, directly in lipid bilayers, using model systems of membrane protein dimerization. We approach these three curious questions with a variety of experimental techniques including membrane protein purification and functional reconstitution, electrophysiology, x-ray crystallography, single-molecule TIRF microscopy and computational modeling.  With this, we are able to fully interrogate the physical driving forces that determine how and why greasy membrane proteins form stable structures inside the greasy lipid membrane.</p>Jon Silva
McKelvey Engineering Awards Engineering Awards2019-04-25T05:00:00Z6 p.m.Saint Louis Art Museum<h3>​Join Dean Aaron Bobick and the McKelvey School of Engineering <br/>
in honoring the 2019 award recipients:</h3><h4></h4><h4>Alumni Achievement Awards</h4><div rtenodeid="3"><strong>Lorrie Cranor, BS ‘92, MS ‘93, MS ‘96, DSc ‘96 </strong></div><div>Director and Bosch Distinguished Professor, Cylab Security and Privacy Institute FORE Systems Professor, Computer Science and Engineering — Carnegie Mellon University<br/></div><div><br/></div><div rtenodeid="4"><strong>Chas Eggert, BS ‘75, MBA ‘85</strong></div><div>Senior Advisor — Arsenal Capital Partners<br/></div><div><br/></div><div rtenodeid="5"><strong>Raj Gupta, BS ‘84</strong></div><div>Executive Chairman — Environmental Systems Design, Inc.<br/></div><div><br/></div><div rtenodeid="6"><strong>Fred Palmerton, BS ‘60</strong></div><div>Founding President (ret.) — Palmerton & Parrish, Inc.<br/></div><h4>Young Alumni Award</h4><div rtenodeid="7"><strong>Deanne Bell, BS ‘02</strong></div><div>TV Host and Founder/CEO — Future Engineers<br/></div><h4>Dean’s Award</h4><div rtenodeid="8"><strong>Don Jubel, BS ‘73</strong></div><div>Executive Chairman — Spartan Light Metal Products LLC<br/></div><div><br/></div><div rtenodeid="9"><strong>Karen Jubel</strong></div><div>Board Member — Spartan Light Metal Products LLC<br/></div><p><br/></p><p></p><div rtenodeid="2"><span><hr/></span><strong><br/></strong></div><div rtenodeid="2"><strong>6 p.m. — Reception</strong></div><div rtenodeid="3"><strong>6:30 p.m. — Program</strong></div><div><strong>Dinner to follow.</strong><br/></div><h4>Please register by April 11. <a href="">RSVP here.</a><br/></h4>Julie Anderson: or 314-935-8730.