Seminar: "Alpha-synuclein, Tau and Complexin: Disordered Proteins in Neurodegeneration and Neurotransmission" "Alpha-synuclein, Tau and Complexin: Disordered Proteins in Neurodegeneration and Neurotransmission"2017-04-27T05:00:00Z10:10 a.m.Whitaker Hall, Room 218<p>​David Eliezer, PhD, Professor of Biochemistry in the Weill Cornell Medical College<br/></p><p>Focus Area: Disease-related proteins <br/></p><p>Host: Jan Bieschke<br/></p>Karen Teasdale, 314-935-4108
Sling Health Demo Day Health Demo Day2017-04-28T05:00:00Z6 p.m.9 p.m.CIC @4240, 4240 Duncan Avenue<p style="color: #202020; font-family: helvetica; margin-top: 10px; margin-bottom: 10px; padding: 0px; line-height: 24px;"><span style="color: #696969;">Sling Health (formerly known as IDEA Labs) is a student-run national biotechnology incubator born on Washington University's campus. Today, the program spans 6 campuses across the country. Demo Day is Sling Health’s flagship event, representing the culmination of the teams’ yearlong progress through the program. Teams showcase their innovations to entrepreneurs, clinicians and investors while they vie in poster and pitch competitions to earn financial prizes from Sling Health.</span></p><p style="color: #202020; font-family: helvetica; margin-top: 10px; margin-bottom: 10px; padding: 0px; line-height: 24px;"><span style="color: #696969;">Demo Day provides teams with the space to unveil their device and software innovations and gain recognition. Teams have the opportunity to build connections with established entrepreneurs, insightful clinicians, and potential investors over dinner and drinks. Financial prizes help jumpstart their transitions into full-fledged companies. Hank Webber, Chairman of Cortex and Executive Vice Chancellor at Washington University, will deliver this year's keynote address. Admission is free.</span></p><p style="color: #202020; font-family: helvetica; margin-top: 10px; margin-bottom: 10px; padding: 0px; line-height: 24px;"><span style="color: #696969;"><a href=""></a><br/></span></p>
Seminar: “Mechanobiology of Breast Tumorigenesis” “Mechanobiology of Breast Tumorigenesis” 2017-04-28T05:00:00Z10:10 a.m.Whitaker Hall, Room 218<p>Karin Wang, NIH NCI Ruth L. Kirschstein NRSA F32 Postdoctoral Fellow at Harvard University, will present.<br/></p>Karen Teasdale, 314-935-4108
Undergraduate Research Symposium Research Symposium2017-05-01T05:00:00ZLab Sciences, Room 300<p>​Professor Phil Bayly will be honored at 4 p.m. with the Chancellor's Award for Outstanding Contributions to Undergraduate Research.<br/></p>
Frank and Grace Yin Distinguished Lectureship in Biomedical Engineering: Jay D. Humphrey, "Central Artery Stiffness in Aging and Disease" and Grace Yin Distinguished Lectureship in Biomedical Engineering: Jay D. Humphrey, "Central Artery Stiffness in Aging and Disease" 2017-05-02T05:00:00Z3 p.m.Whitaker Hall Auditorium<span><div class="twocols first"><h3>"Central Artery Stiffness in Aging and Disease" <br/></h3><p>Central arterial stiffening is both an indicator and an initiator of cardiovascular disease, and aging is a ubiquitous cause of stiffening. In this talk, we will discuss the utility of biomechanical models in understanding particular effects of arterial stiffening on systemic hemodynamics and we will discuss advantages of using mouse models to obtain detailed longitudinal information on regional variations in arterial wall properties. In particular, we will focus on delineating intrinsic material and structural stiffness as a function of location along the aorta and we will show results from 3-D computational simulations of the hemodynamics that account for interactions between the blood and regional wall properties. Amongst the different findings, one emerging concept is that mechano-adaptive responses appear to favor the maintenance of material stiffness near normal values while offsetting increased hemodynamic loads or genetic defects with changes in structural stiffness. Additionally, however, subsequent inflammation-mediated remodeling can lead to maladaptive responses, with significant consequences on both the local mechanobiology and the global physiology.<br/></p></div><div class="twocols"><strong><br/><img src="/Events/PublishingImages/Jay%20Humphrey.jpg?RenditionID=6" class="ms-rtePosition-1" alt="" style="margin: 5px 10px;"/>Jay D. Humphrey</strong><br/>John C. Malone Professor and Chair<br/>Department of Biomedical Engineering<br/>Yale University, New Haven, CT</div></span><h3>Biography</h3><p>"I have 30 years of experience in the field of continuum biomechanics, with primary interest in vascular mechanics and mechanobiology. My lab has considerable experience in the design and construction of novel computer-controlled multiaxial test systems, measurement of vascular mechanical properties, computer-aided histological characterizations, nonlinear constitutive formulations, measurement of in vivo hemodynamics, and computational biomechanics (mainly finite elements). We have formulated a unique "Constrained Mixture Theory" for arterial growth and remodeling (G&R) that has provided significant insight into the biomechanics of arterial adaptations to altered hemodynamics as well as aneurysmal enlargement, vein graft maladaptation, and tissue engineered vascular graft development. We have also developed both a finite element model of the effects of pooled glycosaminoglycans within the aortic wall, a histopathological characteristic unique to thoracic aortic aneurysms and dissections, and a fluid-solid-interaction model of the aortic tree that enables hypothesis generation and testing as well as experimental design. Finally, we have considerable experience with rodent models of vascular disease, including genetically modified, pharmacological, and surgical. We recently published, for example, a first of its kind comparative biomechanical phenotyping of common carotid arteries from 7 different mouse models that suggested that mural cells attempt to maintain material stiffness constant."<br/></p>Karen Teasdale, 314-935-4108
BME Day 2017 Day 20172017-05-02T05:00:00Z8:30 a.m.Whitaker Hall<p>Students and professors from WashU's Department of Biomedical Engineering will make presentations to celebrate the department's impact on our understanding of living systems and the development of new technologies to diagnose and treat disease.</p><table cellspacing="0" width="100%" class="ms-rteTable-0"><tbody><tr class="ms-rteTableEvenRow-0" rtenodeid="505"><td class="ms-rteTableEvenCol-0" rtenodeid="506" style="width: 100px;"><span class="ms-rteStyle-Accent2">​<strong rtenodeid="507">9:30–12:30</strong><br rtenodeid="508"/></span></td><td class="ms-rteTableOddCol-0" rtenodeid="509"><span class="ms-rteStyle-Accent2">​Poster Session – senior design class, MEng, Engineering World Health, Whitaker Hall Atrium<br/><a href="">More Information on Senior Design</a>   <a href="">Class Project Web Pages</a></span></td></tr><tr class="ms-rteTableOddRow-0" rtenodeid="511"><td class="ms-rteTableEvenCol-0" rtenodeid="512" style="width: 100px;"><span class="ms-rteStyle-Accent2">​<strong rtenodeid="513">12:30–1:30</strong><br rtenodeid="514"/></span></td><td class="ms-rteTableOddCol-0" rtenodeid="515"><span class="ms-rteStyle-Accent2" rtenodeid="67">​Lunch – Whitaker Hall Atrium   <strong rtenodeid="65" class="ms-rteForeColor-2">>> </strong></span><a href="" rtenodeid="516"><span class="ms-rteStyle-Accent2" rtenodeid="4"><strong rtenodeid="66" class="ms-rteForeColor-2">Please register for lunch.</strong></span></a><br rtenodeid="517" class="ms-rteStyle-Accent2"/></td></tr><tr class="ms-rteTableEvenRow-0" rtenodeid="518"><td class="ms-rteTableEvenCol-0" rtenodeid="519" style="width: 100px;"><span class="ms-rteStyle-Accent2">​<strong rtenodeid="520">1:30–2</strong><br rtenodeid="521"/></span></td><td class="ms-rteTableOddCol-0" rtenodeid="522"><span class="ms-rteStyle-Accent2">​BME student pitches, Whitaker Hall, Room 100<br rtenodeid="523"/></span></td></tr><tr class="ms-rteTableOddRow-0" rtenodeid="524"><td class="ms-rteTableEvenCol-0" rtenodeid="525" style="width: 100px;"><span class="ms-rteStyle-Accent2">​<strong rtenodeid="526">2–2:45 </strong><br rtenodeid="527"/></span></td><td class="ms-rteTableOddCol-0" rtenodeid="528"><span class="ms-rteStyle-Accent2">​Graduate student research presentations, Whitaker Hall, Room 100<br rtenodeid="529"/></span></td></tr><tr class="ms-rteTableEvenRow-0" rtenodeid="530"><td class="ms-rteTableEvenCol-0" rtenodeid="531" style="width: 100px;"><span class="ms-rteStyle-Accent2">​<strong rtenodeid="532">2:45–3</strong><br rtenodeid="533"/></span></td><td class="ms-rteTableOddCol-0" rtenodeid="534"><span class="ms-rteStyle-Accent2">​Break<br rtenodeid="535"/></span></td></tr><tr class="ms-rteTableOddRow-0" rtenodeid="536"><td class="ms-rteTableEvenCol-0" rtenodeid="537" style="width: 100px;"><span class="ms-rteStyle-Accent2">​<strong rtenodeid="538">3 – 3:10</strong><br rtenodeid="539"/></span></td><td class="ms-rteTableOddCol-0" rtenodeid="540"><span class="ms-rteStyle-Accent2">​Awards announcements – senior design, Whitaker Hall, Room 100<br rtenodeid="541"/></span></td></tr><tr class="ms-rteTableEvenRow-0" rtenodeid="542"><td class="ms-rteTableEvenCol-0" rtenodeid="543" style="width: 100px;"><span class="ms-rteStyle-Accent2">​<strong rtenodeid="544">3:10 – 3:15</strong><br rtenodeid="545"/></span></td><td class="ms-rteTableOddCol-0" rtenodeid="546"><span class="ms-rteStyle-Accent2">​Introduction of the Frank and Grace Yin Distinguished Lectureship in Biomedical Engineering Speaker<br rtenodeid="547"/></span></td></tr><tr class="ms-rteTableOddRow-0" rtenodeid="548"><td class="ms-rteTableEvenCol-0" rowspan="1" rtenodeid="549" style="width: 100px;"><span class="ms-rteStyle-Accent2">​<strong rtenodeid="550">3:15 – 4</strong><br rtenodeid="551"/></span></td><td class="ms-rteTableOddCol-0" rowspan="1" rtenodeid="552"><span class="ms-rteStyle-Accent2" rtenodeid="28">​Frank and Grace Yin Distinguished Lectureship in Biomedical Engineering featuring Jay Humphrey, John C. Malone Professor of Biomedical Engineering and Chair, Yale University: "Central Artery Stiffness in Aging and Disease"   </span><a href="/Events/Pages/BME-Day-2017-Lecture.aspx" rtenodeid="553"><span class="ms-rteStyle-Accent2" rtenodeid="1"><strong rtenodeid="53" class="ms-rteForeColor-2">>> More information</strong></span></a><span class="ms-rteStyle-Accent2" rtenodeid="2"><span class="ms-rteForeColor-2">  <strong rtenodeid="25"></strong></span></span><a href="" rtenodeid="54"><span class="ms-rteStyle-Accent2" rtenodeid="3"><strong rtenodeid="27" class="ms-rteForeColor-2">>> RSVP</strong></span></a><span class="ms-rteStyle-Accent2" rtenodeid="3"></span><br rtenodeid="555" class="ms-rteStyle-Accent2"/></td></tr><tr class="ms-rteTableFooterRow-0"><td class="ms-rteTableFooterEvenCol-0" rowspan="1" rtenodeid="556" style="width: 100px;"><span class="ms-rteStyle-Accent2">​<strong rtenodeid="557">4 – 5</strong> <br rtenodeid="558"/></span></td><td class="ms-rteTableFooterOddCol-0" rowspan="1"><span class="ms-rteStyle-Accent2">​Reception, Whitaker Hall Atrium</span><br rtenodeid="576"/></td></tr></tbody></table><p><br/></p>Karen Teasdale, 314-935-4108