No Classes: Martin Luther King Jr. Day Classes: Martin Luther King Jr. Day2020-01-20T06:00:00Z
BME Seminar: Tim Otchy Seminar: Tim Otchy2020-01-21T06:00:00Z10:00 amRoom 218, Whitaker Hall<p><a href="" rtenodeid="3"><strong>Tim Otchy, PhD</strong></a><br rtenodeid="6"/>Research Assistant Professor of Biology<br/>Center for Systems Neuroscience & Boston University Neurophotonics Center<br/>Boston University<br/><br/><a href="/Events/Documents/Otchy,%20Timothy%20Seminar%20Poster.pdf" rtenodeid="2"><strong>3D-printing at the Micro- and Nano-scale: a new approach to chronic neural-machine interfaces</strong></a></p><p><strong>Abstract:</strong><br/>To investigate neurophysiology, control advanced neuro-prosthetics, and develop neuromodulatory therapeutics, devices that stably record and precisely stimulate the nervous system are required. However, stable, long-term interfacing with the central and peripheral nervous system remains a grand challenge – in part because it requires safely interacting with morphologically complex neural tissues within a biomechanically challenging in vivo environment. Materials and devices constructed at the micro- and nano-scales can circumvent many of the limitations of currently available technologies, allowing us to both interface with tissue more densely and take advantage of the increased biocompatibility and decreased material stiffness as minimum implanted feature sizes shrink to the micron scale. In this seminar, I will present my recent work creating a new class of highly-customizable and ultra-miniaturized interfaces for the nervous system. Central to this is my developing of a novel form of rapid, high-resolution 3D-printing: two-photon resonant direct laser writing (rDLW). My approach makes feasible rapidly fabricating mesoscale devices with nanoscale minimum feature sizes using photopolymers with mechanical, electrical, and optical properties that can be modified programmatically. Using rDLW, I developed a printable device – the nanoclip – for interfacing with fine peripheral nerves in small animal models. In addition to demonstrating chronically stable, high-quality recordings and multi-channel, current-steering-based microstimulation within a very small device geometry, these results constitute a proof of concept for using nanoscale 3D-printing to create implantable devices for mapping and controlling neuronal activity in vivo. I will close with a brief overview of my future research plans for printable bioelectronic and optical interfaces tailored to implant targets in the peripheral and central nervous system.<br/></p><p><strong>Bio:</strong><br/>Dr. Otchy studied Mechanical Engineering at GeorgiaTech and subsequently worked in industry developing machine vision and robotic control systems. He later earned his Master's in Philosophy of Science at Tufts University followed by a PhD in Neuroscience at Harvard University with Bence Ölveczky, where he focused on the neural mechanisms that support the acquisition and adaptation of motor skills in songbirds. In work at Boston University – first as a postdoctoral scientist with Timothy Gardner and now as a Principal Investigator and Research Assistant Professor – he uses novel micro- and nano-fabrication techniques to create chronically stable, high-density bioelectronic and optical interfaces for the peripheral and central nervous system.<br/></p>Barani Raman
LEAP Registration Deadline Registration Deadline2020-01-27T06:00:00Z<p>Win LEAP funding, unleash the impact of your science, advance your research towards commercialization, and develop personal connections with industry experts. Twice per year, the Leadership and Entrepreneurial Acceleration Program (LEAP) awards funding for translational research and inventions with the goal of commercialization. LEAP is open to any person/team with existing or potential WashU intellectual property<br/></p><p>Survey results from the Fall 2019 Cycle showed that 100 percent of participants agreed that "LEAP interactions helped me assess our technology's readiness for commercialization" and they would "recommend participation in LEAP to colleagues." Now it is your chance to participate. Registration for the Spring 2020 Cycle is open now until <strong>end-of-day Monday, Jan. 27</strong>. It only takes a few minutes to apply and can be <a href="" target="_blank">completed online</a>.<br/><br/><strong>Benefits of participating LEAP:</strong></p><ul><li>Be considered for funding (up to $50k for top-scoring projects; one drug discovery project may be awarded $100k per judges decision)<br/></li><li>An educational and interactive process providing:</li><ol><li>Guidance to turn your project into an industry asset with a clear developmental plan for commercialization</li><li>Essential skills to attract commercial funding partners (e.g. federal grants, investors, etc.)</li><li>Feedback from industry experts and opportunities to build long-lasting relationships</li><li>Development of a written summary and presentation for projects as applied to the market</li><li>Access to a dedicated team, led by the Skandalaris Center's Assistant Director of LEAP and Research Innovation, that provides support in navigating the scientific entrepreneurial ecosystem at WUSTL (ICTS, CDD, OTM, etc.)</li></ol></ul><p><strong>BONUS funding and</strong><strong></strong><strong> resources available:</strong></p><p><strong></strong>Sun Pharma Advanced Research Company Limited (SPARC) may provide up to $2 million in value towards the development of a therapeutic. You can indicate your interest in the SPARC support when register.<br/></p>
BME/ESE Seminar: Helen Schwerdt Seminar: Helen Schwerdt2020-01-28T06:00:00Z10:00 amRoom 218, Whitaker Hall<p><strong>​</strong><a href=""><strong>Helen Schwerdt, PhD</strong></a><br rtenodeid="3"/><strong></strong>Research Scientist<br/>McGovern Institute for Brain Reserach<br/>Koch Institute for Integrative Cancer Center<br/>Massachusetts Institute of Technology</p><p><a href="/Events/Documents/Schwerdt,%20Helen%20Seminar%20Poster.pdf" rtenodeid="2"><strong>Multi-Modal Interfaces for Probing Chemical and Electrical Neural Activity Long-Term</strong></a><br/></p><p><strong>Abstract:  </strong><br/></p><p style="text-align: justify;">Dopamine neurochemicals govern key behaviors including movement and motivation.  Dopamine dysregulation is linked to most forms of mood disorders, Parkinson's disease, and many other neurological and neuropsychiatric disorders. In Parkinson's disease, there is a massive loss of dopamine and an abnormal elevation of beta-band electrical signaling throughout the brain, and these are highly correlated with the debilitating loss of normal motor and mood functions. Techniques that allow long-term tracking of these neurochemical and electrical neural signals are needed to identify and intervene at the sources of these diseases. </p><p style="text-align: justify;">I will present on my work focused on addressing key unmet needs in neurochemical interfacing: long-term stability, multi-site monitoring, and synchronous measures of electrical and chemical forms of neural activity. I will describe recent advances in chronic monitoring of dopamine in rodents and primates, where we were able to record these chemical signals over the longest periods following implantation (> 1 year). We recently created multi-modal interfaces to record, for the first time, both chemical and electrical neural activity concurrently. These systems were employed to investigate directly the link between dopamine and beta-band oscillations, prevalent biomarkers of Parkinson's disease, in behaving primates (rhesus monkeys). We further explored the link between these chemical and electrical neural signals and the control of mood and movement behavioral variables that are compromised in Parkinson's. Finally, I will describe my goals of leveraging these new tools to build systems to improve diagnosis and treatment of human disorders.<br/></p><p style="text-align: justify;"><strong>Bio:</strong> <br/>Helen received the B.S in biomedical engineering and M.S.E in electrical and computer engineering from Johns Hopkins University in 2008 and 2009, respectively, and the Ph.D in electrical engineering from Arizona State University in 2014. She was a recipient of the NASA Graduate Student Research Program fellowship to support her graduate work on wireless backscattering microsystems for recording neural activity. Helen is currently a research scientist in the laboratories of Dr. Ann Graybiel and Dr. Michael Cima at the Massachusetts Institute of Technology. She has been working on integrating the fields of microdevice technology and neuroscience with the objective of building clinically viable tools to improve the way we diagnose and treat debilitating neurological disorders including Parkinson's disease and mood disorders. Helen received the NIH Ruth L. Kirschstein National Research Service Award in 2015 to develop chronic interfaces to interrogate deep brain circuits in primates. She was recently awarded the NIH K99/R00 Pathway to Independence Award in 2018 to create novel multi-modal neural interfaces and to implement these to investigate the electrical oscillations and dopamine chemicals that are significantly dysregulated in Parkinson's disease. Helen's long-term goals are to improve treatment of brain disorders by building micro-invasive implants that target the electrical and chemical basis of these diseases with lifelong stability.<br/></p>Barani Raman
BME Seminar: Alexandra Rutz Rutz.aspx2296BME Seminar: Alexandra Rutz2020-01-30T06:00:00Z10:00 amRoom 218, Whitaker Hall<p><a href="" rtenodeid="3"><strong>Alexandra Rutz, PhD</strong></a><br rtenodeid="3"/>Marie Sklodowska-Curie Postdoctoral Fellow<br/>Malliaras Bioelectronics Laboratory<br/>University of Cambridge, Electrical Engineering Division<br/></p><p><a href="/Events/Documents/Rutz,%20Alexandra%20Seminar%20Poster.pdf" rtenodeid="3"><strong>Materials and Additive Manufacturing for Seamless Bioelectronic-tissue Interfaces</strong></a><br/></p><p style="text-align: justify;"><strong>Abstract:</strong></p><p style="text-align: justify;">Remarkable advances in medicine and biology have been made possible with bioelectronics - devices that bridge and connect the worlds of living systems and electronics. Bioelectronics include wearable sensors for health monitoring, in vitro diagnostics, therapeutic implantable devices, and electrical stimulation for tissue engineering and regeneration. Despite their influence, bioelectronic devices are still limited by the fact that they are disparate and distinct from biology. The quality of the device-tissue interface is poor and diminishes with time; this is thought to be due to many factors including significant surgical trauma, an aggressive foreign body response, poor material compatibility with the biological milieu, as well as imprecise and distant connections between electronics and surrounding cells or tissues. Towards addressing these challenges, I will first present the use of slippery surfaces for mitigating the consequences of implanting bioelectronics into delicate tissues. I will demonstrate how liquid-infused elastomers reduce tissue deformation and tearing associated with the insertion of intracortical probes in rats. I will then present how, unlike typical electronic fabrication processes, additive manufacturing is compatible with biomaterials and cells. I will demonstrate that when "inks", processing methods, and scaffold structure are engineered appropriately, extrusion-based 3D printing affords patterned, viable, and functional cell networks, and I will discuss how this can be exploited in future bioelectronic devices. To conclude, I will briefly present my vision to continue tackling the pressing challenges of biointegration that bioelectronics face in expanding their clinical and scientific impacts. The Rutz Lab will engineer "electronic tissues" that merge electronics and biology using additive manufacturing and biomaterials approaches.<br/></p>Lori Setton
BME/IMSE Seminar: Naren Vyavahare, PhD Seminar: Naren Vyavahare, PhD2020-02-03T06:00:00Z1:30 PMRoom 012, Brauer Hall<p><a href="">​<strong>Naren Vyavahare, PhD</strong></a><br/>Professor<br/>Hunter Endowed Chair<br/>Clemson University<br/></p>Co-hosted with IMSE