No Classes: Martin Luther King Holiday Classes: Martin Luther King Holiday2019-01-21T06:00:00Z
Skandalaris Info Session Info Session2019-01-23T06:00:00Z5:30 p.m.Skandalaris Center-Mallinckrodt 128<p>​<span style="color: #212121; font-family: calibri, sans-serif, serif, emojifont; font-size: 14.6667px;">Learn about the opportunities to get involved in Creativity, Innovation & Entrepreneurship at WashU.</span><br/></p>The Skandalaris Center
Spring Internship and Job Career Fair Internship and Job Career Fair2019-01-24T06:00:00Z3 p.m.7 p.m.Athletic Complex<p>The Danforth Campus will host local and national organizations hiring for internships, co-ops, and jobs at the Spring 2019 Internship and Job Career Fair. The fair will provide WashU students a unique opportunity to meet and interview with dozens of potential employers in a short amount of time.</p>Of the fall 2018 fair employers:<div><ul><li>36 percent of the representatives were alumni<br/></li><li>70 percent of the representatives were non-HR staff such as engineers, analysts, managers, operations, and even a few CEOs.<br/></li></ul></div><div>All WashU students and alumni are invited to attend. Professional attire (a suit) is strongly recommended.<br/></div><div><a href="">Register here</a><br/></div>Career Center
CBAC Seminar: Joseph C. Wu Seminar: Joseph C. Wu2019-01-28T06:00:00Z4:00 pmRoom 012, Brauer Hall<p><strong>​Joseph C. Wu, MD, PhD</strong><br/>Director, Stanford Cardiovascular Institute<br/>Simon H. Stertzer, MD, Professor of Medicine & Radiology<br/>Stanford University School of Medicine<br/></p><p><a href="/Events/Documents/WU_Joseph%20FLYER.pdf" rtenodeid="2"><strong>Stem Cells & Genomics for Precision Medicine</strong></a><br/></p>Gwen Nguyen
IdeaBounce®®2019-01-29T06:00:00Z5:30 p.m.7 p.m.Mallinckrodt, Rm 128<p>It's back! <a href="">IdeaBounce®</a> is both an online platform and event for sharing ideas and making connections. This is an opportunity to pitch your idea (no matter how "half-baked"), get feedback on it, and make connections. This event is open to everyone. Appetizers and refreshments provided.<br/></p><p><br/></p>The Skandalaris Center
BME Seminar: Ahmet F. Coskun Seminar: Ahmet F. Coskun2019-01-29T06:00:00Z10:10 AMRoom 012, Brauer Hall<p><strong>​</strong><a href="" rtenodeid="1"><strong>Ahmet F. Coskun, PhD</strong></a><br rtenodeid="5"/>Instructor of Radiology<br/>Stanford University School of Medicine<br/></p><p><a href="/Events/Documents/Coskun,%20Ahmet%20F.%20Poster.pdf" rtenodeid="3"><strong>Multiplex Imaging of Spatial Biology in Single Cells</strong></a><br/></p><p rtenodeid="17"><strong rtenodeid="18"><em>Abstract:</em></strong></p><p rtenodeid="17"><strong rtenodeid="18"><em></em></strong><span style="text-align: justify;"></span></p><p style="text-align: justify;">Spatial organization of cells and subcellular variations in tissues can be considered as a quantitative metric in determining the health and disease states. Single cell analyses of molecular profiles with <em>in-situ </em>detection methods dissect spatial heterogeneity of distinct cell types. Such detailed cellular maps shed light on spatial regulation mechanisms of diseases. </p><p style="text-align: justify;">In this talk, I will introduce multiplex imaging modalities to quantify up to hundred markers at macromolecular resolution in single cells. First, we have devised a "spatial genomics" method (seqFISH) to visualize 3D gene expression profiles in single cells. Using computational modeling of seqFISH data, we have formulated correlation FISH (corrFISH) to resolve dense RNA distributions in immune organs. CorrFISH identified cell-type specific gene expression of ribosomal proteins, a supporting evidence for specialized ribosome theory. Second, we have developed a "subcellular metabolomics" approach, Ion Beam Tomography (IBT), to quantify time-encoded 4D dynamics of chromatin, replication, and transcription at 65-nm lateral and 5-nm axial resolution. IBT revealed spatial segregation of transcription and replication in subcellular volumes of aberrant immune cells, a phase separation model for metabolic regulation of single cells. Lastly, we have demonstrated a "subcellular proteomics" scheme to determine 5D cancer-type specific profiles of nuclear markers in immune/cancer cells within archival patient samples. Super-resolved CODEX protein maps at 100-nm isotropic (x-y-z) resolution in FFPE tissues suggested spatial hierarchical ordering of epigenetics markers, intracellular signaling molecules, and cellular phenotypes in blood cancers. </p><p style="text-align: justify;">Together, image-based molecular profiling, when combined with advanced mathematical theories and computation, has the potential to decode high-dimensional dynamics at the subcellular and molecular level in complex tissues and organs. Automated machine learning algorithms in this single cell big data impact the biomedical practice and clinical care. </p><p><strong rtenodeid="14"><em>Biography:</em></strong></p><p>Dr. Coskun is currently an Instructor of Radiology at Stanford University School of Medicine. Dr. Coskun has been working with Prof. Garry Nolan as a faculty member at Stanford University. Dr. Coskun is an alumnus of the Ignite Entrepreneurship Program at the Stanford University Graduate School of Business. He is a recipient of the National Institutes of Health K25 Career Award (2018), the Burroughs Wellcome Fund CASI Award (2016), and the Leukemia & Lymphoma Research Fellowship (2015). Dr. Coskun previously trained at California Institute of Technology for his postdoctoral work in systems biology. He holds a Ph.D. degree in Electrical Engineering and Bioengineering (Minor) from the University of California, Los Angeles. <br/></p>Barani Raman