https://engineering.wustl.edu/news/Pages/A-simple-sniff.aspx606A simple sniff <video preload="preload" width="100%" height="100%" controls="controls"> <source type="video/mp4" src="https://source.wustl.edu/wp-content/uploads/2017/04/BugStory_Final.mp4"></source> <a href="https://source.wustl.edu/wp-content/uploads/2017/04/BugStory_Final.mp4">https://source.wustl.edu/wp-content/uploads/2017/04/BugStory_Final.mp4</a></video> <p>Engineers at Washington University have discovered a new technique that could change drug delivery to the brain. They were able to apply a nanoparticle aerosol spray to the antenna of locusts, then track the nanoparticles as they traveled through the olfactory nerves, crossed the blood-brain barrier and accumulated in the brain. This new, non-invasive approach could someday make drug delivery as simple as a sniff for patients with brain injuries or tumors.</p><img alt="" src="/news/PublishingImages/washu%20engineering%20locust.jpg?RenditionID=1" style="BORDER:0px solid;" /><div id="__publishingReusableFragmentIdSection"><a href="/ReusableContent/News/34_.000">a</a></div><p>​Delivering life-saving drugs directly to the brain in a safe and effective way is a challenge for medical providers. One key reason: the blood-brain barrier, which protects the brain from tissue-specific drug delivery. Methods such as an injection or a pill aren’t as precise or immediate as doctors might prefer, and ensuring delivery right to the brain often requires invasive, risky techniques.<br/></p><p>​A team of engineers from Washington University in St. Louis has developed a new nanoparticle generation-delivery method that could someday vastly improve drug delivery to the brain, making it as simple as a sniff.</p><p>“This would be a nanoparticle nasal spray, and the delivery system could allow a therapeutic dose of medicine to reach the brain within 30 minutes to one hour,” said Ramesh Raliya, research scientist at the School of Engineering & Applied Science.<br/></p><p></p><p>“The blood-brain barrier protects the brain from foreign substances in the blood that may injure the brain,” Raliya said. “But when we need to deliver something there, getting through that barrier is difficult and invasive. Our non-invasive technique can deliver drugs via nanoparticles, so there’s less risk and better response times.”</p><p>The novel approach is based on aerosol science and engineering principles that allow the generation of monodisperse nanoparticles, which can deposit on upper regions of the nasal cavity via diffusion. Working with Assistant Vice Chancellor Pratim Biswas, chair of the Department of Energy, Environmental & Chemical Engineering and the Lucy & Stanley Lopata Professor, Raliya developed an aerosol consisting of gold nanoparticles of controlled size, shape and surface charge. The nanoparticles were tagged with fluorescent markers, allowing the researchers to track their movement.</p><p>Next, Raliya and biomedical engineering postdoctoral fellow Debajit Saha exposed locusts’ antennae to the aerosol, and observed the nanoparticles travel from the antennas up through the olfactory nerves. Due to their tiny size, the nanoparticles passed through the brain-blood barrier, reaching the brain and suffusing it in a matter of minutes.<br/></p><p>The team tested the concept in locusts because the blood-brain barriers in the insects and humans have anatomical similarities, and the researchers consider going through the nasal regions to neural pathways as the optimal way to access the brain.</p><blockquote>“The shortest and possibly the easiest path to the brain is through your nose,” said Barani Raman, associate professor of biomedical engineering. “Your nose, the olfactory bulb and then olfactory cortex: two relays and you’ve reached the cortex. The same is true for invertebrate olfactory circuitry, although the latter is a relatively simpler system, with supraesophageal ganglion instead of an olfactory bulb and cortex.”</blockquote> <p>To determine whether or not the foreign nanoparticles disrupted normal brain function, Saha examined the physiological response of olfactory neurons in the locusts before and after the nanoparticle delivery. Several hours after the nanoparticle uptake, no noticeable change in the electrophysiological responses was detected.</p><p>“This is only a beginning of a cool set of studies that can be performed to make nanoparticle-based drug delivery approaches more principled,” Raman said.</p><p>The next phase of research involves fusing the gold nanoparticles with various medicines, and using ultrasound to target a more precise dose to specific areas of the brain, which would be especially beneficial in brain-tumor cases.</p><p>“We want to drug target delivery within the brain using this non-invasive approach,” Raliya said.  “In the case of a brain tumor, we hope to use focused ultrasound so we can guide the particles to collect at that particular point.”</p><p>The research was recently published online at <a href="http://www.nature.com/articles/srep44718">Scientific Reports</a>; Raliya may be reached for interviews at <a href="mailto:rameshraliya@wustl.edu">rameshraliya@wustl.edu</a>.<br/></p> <SPAN ID="__publishingReusableFragment"></SPAN> <p> <br/> </p><p>​<br/></p><p> <br/> </p> <span> <div class="cstm-section"><h3>Media Coverage<br/></h3><div> <strong>nanowerk: </strong> <a href="http://www.nanowerk.com/nanotechnology-news/newsid=46382.php">Next-generation nanoparticle nasal spray for drug delivery to the brain</a><br/><br/><strong>Innovation Toronto:</strong> <a href="http://www.innovationtoronto.com/2017/04/a-new-nanoparticle-drug-delivery-method-takes-just-a-sniff/">A new nanoparticle drug delivery method takes just a sniff</a><br/></div></div></span> <p> <br/> </p>Engineers at Washington University in St. Louis used nanoparticles, aerosol technology and locusts in proof of concept research that could someday change the way medicine is delivered to the brain. Erika Ebsworth-Gooldhttps://source.wustl.edu/2017/04/a-simple-sniff/2017-04-12T05:00:00ZA team of engineers from Washington University in St. Louis has combined nanoparticles, aerosol science and locusts in new proof-of-concept research that could someday vastly improve drug delivery to the brain, making it as simple as a sniff.<p>​<span style="font-size: 1.05em;">Nanoparticle research tested in locusts focuses on new drug-delivery method</span></p>
https://engineering.wustl.edu/news/Pages/Detecting-diagnosing-womens-cancers-in-new-ways.aspx594Detecting, diagnosing women’s cancers in new ways<p>​The National Institutes of Health has awarded a Washington University in St. Louis faculty member in the School of Engineering & Applied Science a total of $1.3 million to study new imaging techniques designed to better fight breast and ovarian cancers.<br/></p><img alt="" src="/news/PublishingImages/WashU%20Engineering%20Breast%20Cancer.jpg?RenditionID=1" style="BORDER:0px solid;" /><div id="__publishingReusableFragmentIdSection"><a href="/ReusableContent/News/34_.000">a</a></div><p>​In her research, <a href="/Profiles/Pages/Quing-Zhu.aspx">Quing Zhu</a>, professor of biomedical engineering with a secondary appointment as a professor of radiology at the School of Medicine, combines ultrasound with two additional optical imaging components — diffused near infrared light and photoacoustic waves — to give doctors a more accurate understanding of a patient’s tumor and how to best treat it.</p><p>“We’re hoping down the line that we can give breast oncologists new options to predict who will respond to neoadjuvant chemotherapy and who will not. This will allow them to better determine if a different treatment regimen or earlier surgery is needed,” Zhu said.</p><p>Used on its own, ultrasound can often paint an incomplete picture of a tumor. Zhu has developed a novel approach to combine it with infrared light, which has the ability to track blood vessels and quantify blood volume typically correlated with malignant breast cancers. When used with ultrasound that guides the infrared light to target the lesions, this new technique has the potential to better determine blood volume changes, and then treatment response, on an individualized basis.</p><blockquote>Zhu’s method is designed to be less expensive than an MRI and nuclear imaging, which are commonly used to assess a patient’s response to treatment. </blockquote><p>Early research suggests that after just a couple of weeks, the technique can show how a breast cancer patient’s tumor is responding to a particular chemotherapy regimen, based on the amount of vascular activity and changes. Zhu’s research currently involves patients with three different genetic types of breast cancer (HER2 Positive, Triple Nagative, ER Positive), each requiring its own chemotherapy regimen. She says the combined ultrasound-infrared technique shows promise that it can track a tumor’s response to chemotherapy, regardless of its genetic markers.</p><p>To better detect ovarian cancers, Zhu paired ultrasound with photoacoustic technology to better characterize the ovarian masses and distinguish benign from malignant ovarian tissue. Zhu started with a standard transvaginal ultrasound probe usually used for ovarian exams, then fitted it with a special light delivery channel. Once inserted, the light is absorbed by the suspected tumor, generating a slight temperature change which converts to sound waves. Those sound waves are then analyzed to determine a lesion’s vasculature and oxygen saturation, both markers of a cancerous tumor.</p><blockquote>“Many patients, based on family history and other factors, opt for risk-reduction surgery,” Zhu said.  “Our current screening tools aren’t as effective as we need them to be. This adds a functional extension to the typical ultrasound that can better determine if a lesion is a cancerous tumor, or a benign lesion.”</blockquote> <p>Pilot programs testing both dual-modalities are currently underway in cancer patients treated at Washington University’s School of Medicine. Zhu is working with nearly a dozen different faculty members at the medical school, including: radiologists Steven Poplack, Cary Lynn Siegel, Catherine Appleton, Catherine Young and Kathryn A. Robinson; oncologists Cynthia Ma and Foluso Ademuyiwa; surgeons David Mutch and Matthew Powell; and pathologists Ian Hagemann and Souzan Sanati. Additionally, the entire breast oncology group and OBGYN group are assisting with patient recruiting.</p><p>Zhu’s work is supported by NIH grants R01CA151570-06 and R01EB002136-12.</p><p>“These new technologies are non-invasive imaging approaches, which could allow many women to have a better quality of life if we are successful,” said Zhu.<br/></p> <SPAN ID="__publishingReusableFragment"></SPAN> <p> <br/> </p><p>​<br/></p> <span> <div class="cstm-section"><h3>Professor Quing Zhu<br/></h3><div><p style="text-align: center;"> <a href="/Profiles/Pages/Quing-Zhu.aspx"> <img src="/news/PublishingImages/Zhu_Quing_15.jpeg?RenditionID=3" class="ms-rtePosition-4" alt="" style="margin: 5px;"/></a> <br/></p><div style="text-align: center;"><div style="text-align: center;"> Quing Zhu is a pioneer of combining ultrasound and near infrared (NIR) imaging modalities for clinical diagnosis of cancers and for treatment assessment and prediction of cancers.</div> <br/> <a href="/Profiles/Pages/Quing-Zhu.aspx">View Bio</a></div></div></div></span><br/><br/>An engineer at Washington University in St. Louis is developing new imagine techniques to better diagnose and treat breast cancer (shown) and ovarian cancer.Erika Ebsworth-Gooldhttps://source.wustl.edu/2017/03/detecting-diagnosing-womens-cancers-new-ways/2017-03-29T05:00:00ZThe National Institutes of Health has awarded a Washington University in St. Louis faculty member in the School of Engineering & Applied Science a total of $1.3 million to study new imaging techniques designed to better fight breast and ovarian cancers.
https://engineering.wustl.edu/news/Pages/Scientists-get-closer-look-at-living-nerve-synapses.aspx592Scientists get closer look at living nerve synapses<p>​The brain hosts an extraordinarily complex network of interconnected nerve cells that are constantly exchanging electrical and chemical signals at speeds difficult to comprehend. Now, scientists at Washington University School of Medicine in St. Louis report they have been able to achieve — with a custom-built microscope — the closest view yet of living nerve synapses.<br/></p><img alt="" src="/news/PublishingImages/SynapseKlyachko-760.jpg?RenditionID=1" style="BORDER:0px solid;" /><p>Understanding the detailed workings of a synapse — the junction between neurons that govern how these cells communicate with each other — is vital for modeling brain networks and understanding how diseases as diverse as depression, Alzheimer’s or schizophrenia may affect brain function, according to the researchers.</p><p>The study is published March 23 in the journal Neuron.</p><p>Studying active rat neurons, even those growing in a dish, is a challenge because they are so small. Further, they move, making it difficult to keep them in focus at high magnifications under a light microscope.</p><p>“Synapses are little nanoscale machines that transmit information,” said senior author <a href="/Profiles/Pages/Vitaly-Klyachko.aspx">Vitaly A. Klyachko</a>, an associate professor of cell biology and physiology at the School of Medicine. “They’re very difficult to study because their scale is below what conventional light microscopes can resolve. So what is happening in the active zone of a synapse looks like a blur.</p><blockquote>“To remedy this, our custom-built microscope has a very sensitive camera and is extremely stable at body temperatures, but most of the novelty comes from the analysis of the images,” he added. “Our approach gives us the ability to resolve events in the synapse with high precision.”</blockquote><p>Until now, close-up views of the active zone have been provided by electron microscopes. While offering resolutions of mere tens of nanometers — about 1,000 times thinner than a human hair and smaller — electron microscopes can’t view living cells. To withstand bombardment by electrons, samples must be fixed in an epoxy resin or flash frozen, cut into extremely thin slices and coated in a layer of metal atoms.</p><p>“Most of what we know about the active zone is from indirect studies, including beautiful electron microscopy images,” said Klyachko, also an associate professor of biomedical engineering at the School of Engineering & Applied Science. “But these are static pictures. We wanted to develop a way to see the synapse function.”</p><p>A synapse consists of a tiny gap between two nerves, with one nerve serving as the transmitter and the other as the receiver. When sending signals, the transmitting side of the synapse releases little packages of neurotransmitters, which traverse the gap and bind to receptors on the receiving side, completing the information relay. On the transmitting side of the synapse the neurotransmitters at the active zone are packaged into synaptic vesicles.</p><blockquote>“One of the most fundamental questions is: Are there many places at the active zone where a vesicle can release its neurotransmitters into the gap, or is there only one?” Klyachko said. “A lot of indirect measurements suggested there might be only one, or maybe two to three, at most.”<p></p><p>In other words, if the active zone could be compared to a shower head, the question would be whether it functions more as a single jet or as a rain shower.</p></blockquote> <p>Klyachko and first author Dario Maschi, a postdoctoral researcher, showed that the active zone is more of a rain shower. But it’s not a random shower; there are about 10 locations dotted across the active zone that are reused too often to be left to chance. They also found there is a limit to how quickly these sites can be reused — about 100 milliseconds must pass before an individual site can be used again. And at higher rates of vesicle release, the site usage tends to move from the center to the periphery of the active zone.</p><p>“Neurons often fire at 50 to 100 times per second, so it makes sense to have multiple sites,” Klyachko said. “If one site has just been used, the active zone can still be transmitting signals through its other sites.</p><p>“We’re studying the most basic machinery of the brain,” he added. “Our data suggest these machines are extremely fine-tuned — even subtle modulations may lead to disease. But before we can study disease, we need to understand how healthy synapses work.”<br/></p><p> <br/> </p> <span> <hr/></span> <p>This work was supported in part by the Esther A. & Joseph Klingenstein Fund, the Whitehall Foundation and the McDonnell Center at Washington University.</p><p>Maschi D, Klyachko VA. Spatiotemporal regulation of synaptic vesicle fusion sites in central synapses. Neuron. March 23, 2017.</p><p>Washington University School of Medicine’s 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children’s hospitals. The School of Medicine is one of the leading medical research, teaching and patient-care institutions in the nation, currently ranked seventh in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children’s hospitals, the School of Medicine is linked to BJC HealthCare.<br/></p><p>​<br/></p><p><br/></p> <span> <div class="cstm-section"><h3>Vitaly Klyachko<br/></h3><div><p style="text-align: center;"> <a href="/Profiles/Pages/Vitaly-Klyachko.aspx"> <img src="/Profiles/PublishingImages/Klyachoko_Vitaly.jpg?RenditionID=3" class="ms-rtePosition-4" alt="" style="margin: 5px;"/></a> <br/></p><div style="text-align: center;"> <span style="color: #343434; text-align: center;">Associate Professor, <br/>Biomedical Engineering<br/><br/></span></div><div style="text-align: center;">Associate Professor, Cell Biology and Physiology<br/></div><div style="text-align: center;"> <br/> <a href="/Profiles/Pages/Vitaly-Klyachko.aspx">View Bio</a></div></div></div></span><br/><br/><span> <div class="cstm-section"><h3>Media Coverage<br/></h3><div> <strong>Daily Mail: </strong><a href="http://www.mailonsunday.co.uk/sciencetech/article-4347262/Radical-new-microscope-shows-living-nerve-synapses.html">"The brain up close: Radical microscope reveals nerve synapses firing in breakthrough that could shed light on Alzheimer's and depression"</a><br/></div></div></span><br/>Using a custom-built microscope, scientists have achieved the closest view yet of working nerve synapses, the junctions between neurons that govern how these cells communicate. (Image: Dario Maschi)Julia Evangelou Strait2017-03-23T05:00:00ZScientists at Washington University School of Medicine in St. Louis report they have been able to achieve — with a custom-built microscope — the closest view yet of living nerve synapses.<p>Custom-built microscope reveals details of how neurons communicate<br/></p>
https://engineering.wustl.edu/news/Pages/WashU-engineer-collaborators-win-1-million-international-grant-.aspx591WashU engineer, collaborators win $1 million international grant <p>​A biophysicist in the School of Engineering & Applied Science at Washington University in St. Louis is part of an international team of scientists that has received a three-year, $1 million 2017 Human Frontier Science Program grant to uncover the molecular logic and organization of specialized micrometer-sized structures in cells.<br/></p><img alt="" src="/Profiles/PublishingImages/Pappu_Rohit_1_16_05.jpg?RenditionID=1" style="BORDER:0px solid;" /><div id="__publishingReusableFragmentIdSection"><a href="/ReusableContent/News/34_.000">a</a></div><p><a href="/Profiles/Pages/Rohit-Pappu.aspx">Rohit V. Pappu</a>, the Edwin H. Murty Professor of Engineering in the Department of Biomedical Engineering and director of the Center for Biological Systems Engineering, is part of a team that will use advanced imaging and modeling to answer fundamental questions about membraneless organelles that encompass protein and RNA molecules and serve as micro-reactors and stress response depots in cells. Their work will focus on uncovering the organization of membraneless organelles and the selective permeability of biomolecules into these organelles. </p><p>These studies are directly relevant to understanding how cells control crucial decision-making processes such as division, movement and programmed death. In addition, the proposed studies will have a direct impact on understanding how membraneless organelles serve as crucibles for degenerative processes in diseases such as ALS and in proliferative processes that give rise to cancers. </p><p>Pappu is part of a team that includes Stephen W. Michnick of the Department of Biochemistry at the University of Montreal, who is principal investigator, and Simon Alberti, a group leader at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. </p><p>The highly competitive Research Grants provide support for international teams with members from at least two countries. Team members are expected to broaden the character of their research compared with their ongoing research programs and interact with teams bringing expertise different from their own to create novel approaches to problems in fundamental biology. In 2017, the program awarded $30 million to support the top 3 percent of Research Grant Applications.  <br/></p><SPAN ID="__publishingReusableFragment"></SPAN><p><br/></p><br/><br/> ​ <div class="cstm-section"><h3>​Global Collabo​rators​</h3><div style="text-align: left;"> <strong><a href="/Profiles/Pages/Rohit-Pappu.aspx"><strong>Rohit Pappu</strong></a><br/> </strong> </div><div style="text-align: left;"> <span style="font-size: 12px;">​​​Professor, ​Biomedical Engineering<br/>Washington University in St. Louis</span></div><div style="text-align: left;"> <strong><br/> </strong> </div><div style="text-align: left;"> <strong> <a href="/Profiles/Pages/Srikanth-Singamaneni.aspx"> </a></strong></div> <a href="http://michnick.bcm.umontreal.ca/"> <div style="text-align: left;">​​​<strong>Stephen W. Michnick</strong><br/></div></a> <div style="text-align: left;"> <span style="font-size: 12px;">Department of Biochemistry</span></div><div style="text-align: left;"> <span style="font-size: 12px;">​University of Montreal</span> </div><div style="text-align: left;"> <span style="font-size: 12px;"> <br/></span></div><div style="text-align: left;"><div></div><div></div></div><div><div style="color: #343434; line-height: 20.8px; text-align: left;"> <strong> <a href="https://www.mpi-cbg.de/research-groups/current-groups/simon-alberti/research-focus/"> <strong>Simon Alberti</strong></a></strong></div><div style="color: #343434; line-height: 20.8px; text-align: left;"> <span style="font-size: 12px;">Max Planck Institute of Molecular Cell Biology and Genetics</span><span style="font-size: 1em;"> ​</span><span style="font-size: 1em;">​​​​​</span></div></div></div>  ​ Rohit Pappu2017-03-22T05:00:00ZRohit Pappu is part of an international team of scientists that has received a three-year, $1 million 2017 Human Frontier Science Program grant.
https://engineering.wustl.edu/news/Pages/Engineering-students-receive-prestigious-Graduate-Research-Fellowships-.aspx588Engineering students receive prestigious Graduate Research Fellowships <p>​Three seniors and a doctoral student in the School of Engineering & Applied Science at Washington University in St. Louis have been chosen for the competitive National Science Foundation Graduate Research Fellowship. <br/></p><img alt="" src="/news/PublishingImages/washu%20engineering%20commencement.JPG?RenditionID=2" style="BORDER:0px solid;" /><p>The fellowship, the oldest of its kind, awards a three-year annual stipend of $34,000 as well as a $12,000 allowance for tuition and fees, opportunities for international research and professional development, and the freedom to conduct research at any accredited U.S. institution of graduate education. From more than 13,000 applications received for the 2017 competition, the NSF awarded 2,000 fellowships.</p><p>The new fellows are:</p><ul><li><p><strong>Savannah Est</strong>, a senior majoring in biomedical engineering with a minor in materials science & engineering;</p></li><li><p><strong>Roger Albert Iyengar</strong>, a senior majoring in computer science; </p></li><li><p><strong>Corban Swain</strong>, a senior majoring in biomedical engineering;</p></li><li><p><strong>Ian Berke</strong>, a first-year doctoral student in biomedical engineering. </p></li></ul><p>Three undergraduate Engineering students and two alumni received honorable mentions, which is considered a significant national academic achievement. They are: </p><ul><li><p><strong>Ananya Benegal</strong>, a senior majoring in biomedical engineering with a minor in mechanical engineering and a master's student in mechanical engineering;</p></li><li><p><strong>Arnold Tao</strong>, a senior majoring in biomedical engineering;</p></li><li><p><strong>Louis Shen Wang</strong>, a senior majoring in chemical engineering with a minor in chemistry;</p></li><li><p><strong>Timothy Bartholomew</strong>, who earned a bachelor's degree in chemical engineering in 2015 and is now a graduate student at Carnegie-Mellon University.</p></li><li><p><strong>Pratik Singh Sachdeva</strong>, who earned a bachelor's degree in applied science in 2015 and is now a graduate student at the University of California, Berkeley.<br/></p></li></ul><p>The Graduate Research Fellowship has a history of selecting recipients who achieve high levels of success in their future academic and professional careers. Many become life-long leaders that contribute significantly to both scientific innovation and teaching. Past fellows include numerous Nobel Prize winners; U.S. Secretary of Energy Steven Chu; Google founder Sergey Brin; and Freakonomics co-author Steven Levitt. Since 1952, NSF has funded more than 50,000 Graduate Research Fellowships out of more than 500,000 applicants. <br/></p>Beth Miller 2017-03-20T05:00:00ZThree seniors and a doctoral student have been chosen for the competitive National Science Foundation Graduate Research Fellowship.
https://engineering.wustl.edu/news/Pages/WashU-Women-Crowned-Indoor-T-F-National-Champions.aspx611WashU Women Crowned Indoor Trach & Field National Champions<p>Kelli Hancock and Deko Ricketts, senior WashU engineers, were among award winners at the 2017 NCAA Division III Indoor Track & Field National Championship​.<br/></p><img alt="" src="/news/PublishingImages/washu%20engineers%20track%20and%20field%20champions.jpg?RenditionID=1" style="BORDER:0px solid;" /><p>Washington University in St. Louis women's track & field captured the 2017 NCAA Division III Indoor Track & Field National Championship during the two-day event at North Central College, the first title in program history and 21st overall National Championship in school history. The men's program placed 17th with 11.5 points from two senior members of the team.<br/></p><p>The women scored 44 points to lead the field, supplanting the runner-up Ithaca College (41.25) during the final women's race of the day. Seniors <a href="http://bearsports.wustl.edu/sports/track/2016-17/bios/ridderhoff_rebecca_2k9m">Rebecca Ridderhoff</a>, <a href="http://bearsports.wustl.edu/sports/track/2016-17/bios/hancock_kelli_vupq">Kelli Hancock</a>, <a href="http://bearsports.wustl.edu/sports/track/2016-17/bios/knudson_ashley_ksr0">Ashley Knudson</a> and <a href="http://bearsports.wustl.edu/sports/track/2016-17/bios/ogede_daisy_w0d3">Daisy Ogede</a> raced to a second place finish in the 4x400 Relay. Ogede crossed the finish line as the Bears slowly came to the realization that the eight points awarded to the second place team were more than enough to pass up Ithaca for the National Championship.</p><p>Senior <a href="http://bearsports.wustl.edu/sports/track/2016-17/bios/ricketts_deko_e0wz">Deko Ricketts</a> also earned a National Championship finish in the 800 for the men. The 800 began with University of Wisconsin-La Crosse pushing the tempo. Ricketts made his move on the final lap with around 150m remaining to take the lead and capture the 800 title with a season-best time of 1:51.07.</p><p>Ridderhoff was no stranger to scoring points for the Bears as she raced to four All-American finishes during the final day. In addition to helping the 4x400 relay team to a runner-up finish, she placed seventh in three events individually. Ridderhoff totaled six points in the 60 hurdles (9.01), 400 (56.49) and the 200 (25.45).</p><p>Ogede also ran to multiple All-American finishes individually. She placed second in the 60 with a new school record 7.56 time, which moves her into a tie for ninth best all-time in Division III indoor history. Ogede followed the record time with a third place finish in the 200 (24.97) before anchoring the 4x400 Relay team.</p><p>Also earning All-American status for the second indoor season in a row was junior <a href="http://bearsports.wustl.edu/sports/track/2016-17/bios/wagner_annalise_hvc4">Annalise Wagner</a>. She raced to a third place finish in the 800 (2:13.22) scoring six points for the Bears.</p><p>Junior <a href="http://bearsports.wustl.edu/sports/track/2016-17/bios/lindsay_alison_g4am">Alison Lindsay</a> finished 13th in the 3,000 (10:09.52) one day after helping the distance medley relay team to a national title by running the 1,600m leg of the race.<br/></p><p>The Bears are the first track & field team in the University Athletic Association (UAA) to win the National Championship.<br/></p>bearsports.wustl.eduhttp://bearsports.wustl.edu/sports/track/2016-17/releases/20170311ymgvvc2017-03-11T06:00:00ZEngineering seniors Kelli Hancock and Deko Ricketts were among award winners at the 2017 NCAA Division III Indoor Track & Field National Championship.