McKelvey Engineering faculty receive LEAP awards<img alt="" src="/news/PublishingImages/Shantanu%20Genin%20Yang%20Zhou%20.jpg?RenditionID=1" style="BORDER:0px solid;" /><div id="__publishingReusableFragmentIdSection"><a href="/ReusableContent/36_.000">a</a></div><p>Four McKelvey School of Engineering faculty members received awards from the Skandalaris Center's Leadership and Entrepreneurial Acceleration Program (LEAP).</p><p>The LEAP Awards support Washington University faculty developing a product or innovation and provide industry connections and gap funding to stimulate Washington University technology commercialization, illuminate investment risk and rapidly accelerate development of validated projects.  </p><p>Out of 25 teams that entered, <a href="">10 received awards</a> supported by funding from the Institute of Clinical and Translational Sciences, Siteman Cancer Center, Skandalaris Center for Interdisciplinary Innovation and Entrepreneurship, McKelvey School of Engineering, and Center for Drug Discovery.<br/></p><p>The McKelvey Engineering faculty who received awards are:</p><ul><li>Shantanu Chakrabartty, professor of electrical & systems engineering, with Joe Beggs, an undergraduate student; Yarub Alazzawi, a doctoral student; and Kenji Aono, a postdoctoral research associate, for a project titled "SelfCap, self-capacitance based wireless powering technology that improves the aesthetic value and user compliance of wearables and semi-invasive biosensors by reducing its form-factor and battery requirements.<br/></li><li>Guy Genin, professor of mechanical engineering & materials science, with John M. Felder, assistant professor of surgery at the School of Medicine, for a project titled "Barbed Mesh for Sutureless Tissue Fixation, a mesh that can be used for fixating tissues, such as abdominal fascia, and skin, that eliminates the need for traditional suturing and saves OR time."<br/></li><li>Lan Yang, professor of electrical & systems engineering, with Jie Liao, a doctoral student; and Abraham J. Qavi, a postdoctoral research associate, for a project titled "Seeing Sound: Redefining Hear Aids Through Light, optical sensors that will drastically improve the performance of hearing aids.<br/></li><li>Chao Zhou, associate professor of biomedical engineering, with Rajendra Apte, MD, PhD, the Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Sciences at the School of Medicine, and Jason Jerwick, a doctoral student in biomedical engineering, for a project titled "Ultrahigh speed optical coherence tomography, a novel, patented technology that offers over 10x speed improvement in eye scans while being compatible/ retrofit-able with tens of thousands of OCT devices in the market."</li></ul><SPAN ID="__publishingReusableFragment"></SPAN><br/>(Clockwise) Shantanu Chakrabartty, Guy Genin, Lan Yang, Chao Zhou2020-03-12T05:00:00ZFour faculty members in the McKelvey School of Engineering recently received awards to prepare their products for commercialization.,-living-human-hearts.aspx1259Rudy lab conducts first study of electromechanics of healthy, living human hearts<div class="youtube-wrap"><div class="iframe-container"> <iframe width="560" height="315" src="" frameborder="0" allow="accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture"></iframe>   <br/></div></div><br/><img alt="" src="/news/PublishingImages/Rudy%20Chris%20Andrews.jpg?RenditionID=1" style="BORDER:0px solid;" /><div id="__publishingReusableFragmentIdSection"><a href="/ReusableContent/36_.000">a</a></div><p>While there have been numerous studies of abnormalities in the human heart, there have not been studies of the electromechanics of healthy adult hearts — until now. Yoram Rudy, the Fred Saigh Distinguished Professor of Engineering in the McKelvey School of Engineering, and Christopher Andrews, a postdoctoral research scholar in the Department of Biomedical Engineering, have completed the first study to combine electrocardiographic imaging (ECGI), a noninvasive method developed in the Rudy lab, with tagged MRI to study the electromechanics of healthy hearts in living humans.</p><p>ECGI is a noninvasive imaging method that maps the heart's electrical activity using electrocardiographic measurements from about 250 body surfaces together with the heart-torso geometry from anatomical MRI or computed tomography (CT) scans. The electrocardiographic measurements and geometrical information are combined mathematically to create maps of the cardiac electrical excitation. Tagged MRI measures displacement of heart-muscle regions, providing a 3D image of cardiac strain during contraction.  </p><p>The study conducted ECGI and tagged MRI on 20 healthy adult volunteers at Washington University in St. Louis, making it the largest ECGI study of healthy adults to date and the first study of electromechanics coupling in living normal human hearts.</p><p>In the study, Rudy and Andrews, along with Brian Cupps, a senior scientist in the Department of Surgery, and Michael K. Pasque, MD, professor of surgery, both at Washington University School of Medicine, found that electrical excitation was very fast compared to mechanical contraction; it started at the antero-lateral region of the right ventricle and ended in the base of the left ventricle. There was a difference in the duration of local electrical excitation between men and women subjects; women had a longer mean activation-recovery interval than men by about 30 milliseconds. This highlights the sensitivity of ECGI in measuring cardiac repolarization.</p><p>The data could be helpful in designing and validating mathematical models of the heart's electromechanics for the study of human cardiac electrophysiology and mechanics.</p><p>"The ability to image noninvasively the electrical and mechanical function in the same human heart in vivo carries great promise for clinical diagnosis and guidance of treatment in various cardiac disorders, such as heart failure," Rudy said.  </p><SPAN ID="__publishingReusableFragment"></SPAN><p> </p><p>Funding for this study was provided by the National Institutes of Health National Heart, Lung, and Blood Institute (R01-HL-033343 and R01-HL-049054; Washington University Institute of Clinical and Translational Sciences (UL-TR000448).</p><p>Andrews C, Cupps B, Pasque M, Rudy Y. Electromechanics of the Normal Human Heart In Situ. <em>Circulation: Arrhythmia and Electrophysiology</em>, 2019; 12:e007484. DOI: 10.1161/CIRCEP.119.007484.<br/></p><div><div class="cstm-section"><h3>Yoram Rudy<br/></h3><div style="text-align: center;"> <strong> <a href="/Profiles/Pages/Yoram-Rudy.aspx"> <img src="/Profiles/PublishingImages/Rudy_Yoram.jpg?RenditionID=3" alt="" style="margin: 5px;"/></a> <br/><a href="/Profiles/Pages/Yoram-Rudy.aspx"><strong></strong></a></strong></div><div style="text-align: center;"><ul style="text-align: left;"><li>Fred Saigh Distinguished Professor of Engineering</li><li>Research: Rhythm disorders of the heart lead to over 400,000 cases of sudden death annually in the U.S. alone. Yoram Rudy's research aims at understanding the mechanisms that underlie normal and abnormal rhythms of the heart at various levels, from the molecular and cellular to the whole heart.<br/></li></ul><p> <a href="/Profiles/Pages/Yoram-Rudy.aspx">View Bio</a><br/></p></div></div><div class="cstm-section"><h3>Christopher Andrews<br/></h3><div style="text-align: center;"> <strong> <img src="/news/PublishingImages/chrisandrews.jpg?RenditionID=3" alt="" style="margin: 5px;"/> <br/><strong></strong></strong></div><div style="text-align: center;"><ul style="text-align: left;"><li>Postdoctoral Research Scholar<br/></li></ul></div></div></div>2020-02-26T06:00:00ZYoram Rudy and Christopher Andrews have completed the first study using a noninvasive imaging method using healthy living human hearts BME undergraduate program ranked No. 6 by 'Successful Student'<img alt="" src="/news/PublishingImages/Pages/washu-bme-undergraduate-program-ranked-6-by-successful-student/190401_mckelvey_engineering_192.jpg?RenditionID=1" style="BORDER:0px solid;" /><p>The McKelvey School of Engineering’s undergraduate biomedical engineering program was ranked No. 6 on Successful Student’s list of the "<a href="" target="_blank">Best Bachelor's in Biomedical Engineering Programs</a>.”</p> <p>The ranking was based on publications and citations by faculty and alumni, as well as degrees offered, coursework, opportunities for hands-on instruction and the institution’s academic reputation.</p><p>Since its founding in 1997, the Department of Biomedical Engineering at Washington University in St. Louis has combined innovative research with a first-class engineering education to prepare students to succeed in current and future paths in biomedical engineering.</p><p>"We have more than 250 undergraduate engineering students annually who participate in mentored research opportunities and take courses across multiple disciplines," said Lori Setton, the Lucy & Stanley Lopata Distinguished Professor of Biomedical Engineering and department chair. "Together with early faculty contact and many laboratory offerings, we prepare our undergraduates so they can succeed when employed or when continuing on for graduate or medical school."<br/></p><p>The department is comprised of 21 full-time faculty and supported by nearly 100 affiliated faculty. The full-time faculty includes eight AIMBE fellows, three BMES fellows, two American Heart Association Fellows and one member of the National Academy of Engineering.</p><p>Along with this accolade, the department has been named the No. 18 best undergraduate biomedical engineering program by <em>U.S. News & World Report</em> and the No. 10 best BME program by College Choice.</p>WashU's Department of Biomedical Engineering is comprised of 21 full-time faculty and nearly 100 affilate faculty from the School of Engineering and School of Medicine. Photo by Whitney CurtisDanielle Lacey2020-02-26T06:00:00ZThe website recognized the McKelvey School of Engineering for the prestige of its faculty publications, degrees offered and academic reputation. selected to serve with Center for Scientific Review study section<img alt="Jon Silva" src="/Profiles/PublishingImages/Silva_Jon.jpg?RenditionID=6" style="BORDER:0px solid;" /><p>Jonathan Silva, associate professor of biomedical engineering at the McKelvey School of Engineering, has been selected to serve as a permanent member of the Electrical Signaling, Ion Transport and Arrhythmias Study Section with the Center for Scientific Review. His term will begin on July 1. </p><p>"Serving on the study section is an exciting opportunity to apply my combined experimental and computational background to help identify the best science for funding," Silva said. </p><p>Silva was recognized for his "demonstrated competence and achievement in his scientific discipline." Silva's research applies computational and biophysical methods to improve arrhythmia treatments. <a href="/news/Pages/New-model-of-irregular-heartbeat-could-boost-drug-efficacy.aspx">His most recent paper</a> shared his lab's findings following the development of the first computational model that identified situations where a popular drug used to treat arrhythmia will be successful. </p><p>As a member of the study section, Silva will have the opportunity to contribute to the nation's biomedical research effort through the National Institutes of Health (NIH). The study section reviews grant applications, makes recommendations to the advisory boards and oversees research in the field. <br/></p>Jon SilvaDanielle Lacey2020-02-25T06:00:00ZJonathan Silva, associate professor of biomedical engineering, will serve as a standing member of the Electrical Signaling, Ion Transport and Arrhythmias Study Section beginning July 1. Expert: Ingredients for a virus to become a pandemic<div class="youtube-wrap"><div class="iframe-container"> <iframe width="560" height="315" src="" frameborder="0" allow="accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture"></iframe>    </div> </div><br/><img alt="" src="/Profiles/PublishingImages/Vahey,%20Mike.jpg?RenditionID=1" style="BORDER:0px solid;" /><p>​As of Feb. 25, 2020, the World Health Organization reported 79,339 confirmed cases of novel coronavirus, also known as COVID-19. Thirty-four countries have reported cases, including 2,619 deaths.</p><p>The WHO has not declared COVID-19 as a pandemic — a situation defined somewhat vaguely by the WHO as “the worldwide spread of a new disease.”</p><p><a href="/Profiles/Pages/Michael-Vahey.aspx">Michael Vahey</a>, assistant professor of biomedical engineering at the McKelvey School of Engineering at Washington University in St. Louis, researches viruses and the mechanisms and circumstances that make them more or less capable of reaching pandemic status.</p><p>In the past, the world has seen pandemics infect and kill millions: The 1918 influenza is estimated to have killed 50 million and the bubonic plague killed an estimated 25 million people in Europe — one third of the continent’s population.</p><p>In this video, Vahey explains the properties of a virus that allow it to spread so rapidly across the world, reaching pandemic status:</p><ul><li><p>Viruses that become pandemics are usually zoonotic in nature; they have made the leap from non-human animals into humans.</p></li></ul><ul><li><p>Once in humans, viruses need to be able to survive and thrive in their new environment if they are to reach pandemic status.</p></li></ul><ul><li><p>Pandemic viruses also need to be able to spread efficiently from human to human in order to infect people around the globe.</p></li></ul><p>Vahey also offers some advice for predicting and preparing for emerging pandemics.</p><p>He is scheduled to speak Feb. 26 in Thailand at a National Institutes of Health Conference on Emerging Infectious Diseases in the Pacific Rim.<br/></p><div><div class="cstm-section"><h3> Michael Vahey<br/></h3><div style="text-align: center;"> <strong><a href="/Profiles/Pages/Michael-Vahey.aspx"><img src="/Profiles/PublishingImages/Vahey,%20Mike.jpg?RenditionID=3" alt="" style="margin: 5px;"/></a> <br/><a href="/Profiles/Pages/Michael-Vahey.aspx"><strong></strong></a></strong></div><div style="text-align: center;"><ul style="text-align: left;"><li>Assistant Professor of Biomedical Engineering<br/></li><li>Research: D<span style="font-size: 1em;">eveloping imaging methods and microfluidic technologies to understand infectious diseases, with an emphasis on studying how viruses like influenza A navigate and shape their hosts in order to replicate</span><br/></li></ul><p> <a href="/Profiles/Pages/Michael-Vahey.aspx">View Bio</a><br/></p></div></div></div>Brandie Jefferson novel coronavirus have the potential to become a pandemic?<p>​Does novel coronavirus have the potential to become a pandemic?<br/></p>Y