​​

 

 

https://engineering.wustl.edu/news/Pages/Pappu-named-2019-Biophysical-Society-Fellow.aspx929Pappu named 2019 Biophysical Society Fellow<img alt="" src="/Profiles/PublishingImages/Pappu_Rohit_1_16_05.jpg?RenditionID=1" style="BORDER:0px solid;" /><p>The Biophysical Society (BPS) recently named a bioengineer from Washington University in St. Louis as one of its 2019 Society Fellows.</p>Rohit Pappu, the Edwin H. Murty Professor of Engineering in the School of Engineering & Applied Science, will be honored along with the other BPS Fellows during the society’s annual meeting in March.<div><br/>The designation honors the society’s distinguished members who have demonstrated excellence in science, contributed to the expansion of the field of biophysics, and supported the Biophysical Society throughout their careers.<br/></div>The Sourcehttps://source.wustl.edu/2018/09/pappu-named-2019-biophysical-society-fellow/2018-09-17T05:00:00ZThe Biophysical Society (BPS) recently named the bioengineer from Washington University in St. Louis as one of its 2019 Society Fellows.
https://engineering.wustl.edu/news/Pages/Silva-named-fellow-of-the-American-Heart-Association.aspx930Silva named fellow of the American Heart Association<img alt="" src="/Profiles/PublishingImages/Silva_Jon.jpg?RenditionID=1" style="BORDER:0px solid;" /><p>Jon Silva, associate professor of biomedical engineering, has been named a fellow of the American Heart Association. Silva's fellowship, granted by the Council on Basic Cardiovascular Sciences, recognizes and awards scientific and professional accomplishments, volunteer leadership and service.</p><p>Silva, who applies computational and biophysical methods to improve arrhythmia therapies, will be recognized at a November event in Chicago. <br/></p>Jon Silva2018-09-17T05:00:00ZJon Silva has been named a fellow of the American Heart Association.
https://engineering.wustl.edu/news/Pages/Researchers-show-protein-deficiency,-stress-contribute-to-loss-of-contractions-in-heart-tissues-.aspx922Researchers show protein deficiency, stress contribute to loss of contractions in heart tissues <img alt="" src="/Profiles/PublishingImages/Huebsch_Nate.jpg?RenditionID=1" style="BORDER:0px solid;" /><p>​Nate Huebsch, assistant professor of biomedical engineering, was among a team of researchers that unveiled new information about the mechanobiology of heart tissues. In research published Sept. 10 in<em> </em><a href="https://www.nature.com/articles/s41551-018-0280-4" rtenodeid="9"><em>Nature Biomedical Engineering</em></a>, the team found that cardiac tissue was unable to contract properly when deficient of the protein MYBPC3 but only when subjected to a mechanically rigid environment. Huebsch participated in the research as an associate project specialist at the University of California-Berkeley. <br/></p>Nate Huebsch2018-09-10T05:00:00ZNate Huebsch was part of a team that published new information about the mechanobiology of heart tissues in Nature Biomedical Engineering.
https://engineering.wustl.edu/news/Pages/Focused-delivery-for-brain-cancers.aspx917Focused delivery for brain cancers<div class="youtube-wrap"><div class="iframe-container"> <iframe width="854" height="480" frameborder="0" src="https://www.youtube.com/embed/c2qTVXxIdyU"></iframe> <br/> <br/> <br/></div></div><img alt="" src="/news/PublishingImages/Hong-Chen-brain.jpg?RenditionID=1" style="BORDER:0px solid;" /><div id="__publishingReusableFragmentIdSection"><a href="/ReusableContent/36_.000">a</a></div><p>​A person’s brainstem controls some of the body’s most important functions, including heart beat, respiration, blood pressure and swallowing. Tumor growth in this part of the brain is therefore twice as devastating. Not only can such a growth disrupt vital functions, but operating in this area is so risky, many medical professionals refuse to consider it as an option.</p><p>New, interdisciplinary research from Washington University in St. Louis has shown a way to target drug delivery to just that area of the brain using noninvasive measures, bolstered by a novel technology: focused ultrasound.</p><p>The research comes from the lab of <a href="/Profiles/Pages/Hong-Chen.aspx">Hong Chen</a>, assistant professor of biomedical engineering in the School of Engineering & Applied Science and assistant professor of radiation oncology at Washington University School of Medicine in St. Louis. Chen has developed a novel way in which ultrasound and its contrast agent — consisting of tiny bubbles — can be paired with intranasal administration, to direct a drug to the brainstem and, potentially, any other part of the brain.<br/></p><p></p><p>The research, which included faculty from the Mallinckrodt Institute of Radiology and the Department of Pediatrics at the School of Medicine, along with faculty from the Department of Energy, Environmental & Chemical Engineering in the School of Engineering & Applied Science, was published online this week and will be in the Sept. 28 issue of the <a href="https://www.sciencedirect.com/science/article/pii/S0168365918304140">Journal of Controlled Release</a>.</p><p>This technique may bring medicine one step closer to curing brain-based diseases such as diffuse intrinsic pontine gliomas (DIPG), a childhood brain cancer with a five-year survival rate of a scant two percent, a dismal prognosis that has remained unchanged over the past 40 years. (To add perspective, the most common childhood cancer, acute lymphoblastic leukemia, has a <a href="https://www.cancer.gov/types/childhood-cancers/child-adolescent-cancers-fact-sheet">five-year survival rate of nearly 90 percent.</a>)<br/></p><p></p><p>“Each year in the United States, there are no more than 300 cases,” Chen said. “All pediatric diseases are rare; luckily, this is even more rare. But we cannot count numbers in this way, because for kids that have this disease and their families, it is devastating.”</p><p>Chen’s technique combines Focused UltraSound with IntraNasal delivery, (FUSIN). The intranasal delivery takes advantage of a unique property of the olfactory and trigeminal nerves: they can carry nanoparticles directly to the brain, bypassing the blood brain barrier, an obstacle to drug delivery in the brain.</p><p>This unique capability of intranasal delivery was demonstrated last year by co-authors<a href="https://sites.wustl.edu/rameshraliya"> Ramesh Raliya</a>, research scientist, and<a href="/Profiles/Pages/Pratim-Biswas.aspx"> Pratim Biswas</a>, assistant vice chancellor and chair of the Department of Energy, Environmental & Chemical Engineering and the Lucy & Stanley Lopata Professor, in their<a href="https://www.nature.com/articles/srep44718"> 2017 publication in Scientific Reports</a>.</p><p>“At the beginning, I couldn’t even believe this could work,” Hong said of delivering drugs to the brain intranasally. “I thought our brains are fully protected. But these nerves actually directly connect with the brain and provide direct access to the brain.”</p><p>While nasal brain drug delivery is a huge step forward, it isn’t yet possible to target a drug to a specific area. Chen’s targeted ultrasound technique is addressing that problem.</p><p>When doing an ultrasound scan, the contrast agent used to highlight images is composed of microbubbles. Once injected into the bloodstream, the microbubbles behave like red blood cells, traversing the body as the heart pumps.</p><p>Once they reach the site where the ultrasound wave is focused, they do something unusual.</p><p>“They start to expand and contract,” Chen said. As they do so, they act as a pump to the surrounding blood vessels as well as the perivascular space — the space surrounding the blood vessels.</p><p>“Consider the blood vessels like a river,” Chen said. “The conventional way to deliver drugs is to dump them in the river.” In other parts of the body, the banks of the river are a bit “leaky,” Chen said, allowing the drugs to seep into the surrounding tissue. But the blood brain barrier, which forms a protective layer around blood vessels in the brain, prevents this leakage, particularly in the brains of  young patients, such as those with with DIPG.</p><p>“We will deliver the drug from the nose to directly outside the river,” Chen said, “in the perivascular space.”</p><p>Then, once ultrasound is applied at the brain stem, the microbubbles will begin to expand and contract. The oscillating microbubbles push and pull, pumping the drug toward the brainstem. This technique also addresses the problem of drug toxicity — the drugs will go directly to the brain instead of circulating through the whole body. In collaboration with <a href="https://www.mir.wustl.edu/research/research-laboratories/radiological-chemistry-and-imaging-laboratory-rcil/people/yongjian-liu">Yongjian Liu</a>, associate professor of radiology, and <a href="https://www.mir.wustl.edu/research/research-laboratories/radiological-chemistry-and-imaging-laboratory-rcil/people/bio-template3/yuan-chuan-tai">Yuan-Chuan Tai</a>, associate professor of radiology, Chen used positron emission tomography (PET scan) to verify that there was minimal accumulation of intranasal-administered nanoparticles in major organs, including lungs, liver, spleen, kidney and heart.</p><p>So far, Chen’s lab has had success using their technique in mice for the delivery of gold nanoclusters made by the team led by Liu.</p><p>“The next step is to demonstrate the therapeutic efficacy of FUSIN in the delivery of chemotherapy drugs for the treatment of DIPG,” said <a href="https://chenultrasoundlab.wustl.edu/people/dezhuang-summer-ye/">Dezhuang Ye</a>, lead author of the paper, who is Chen’s graduate student from the <a href="https://mems.wustl.edu/Pages/default.aspx">Department of Mechanical Engineering & Materials Science</a>. The lab has also teamed up with Biswas to develop a new aerosol nasal delivery device to scale up the technique from a mouse to a large animal model.</p><p>Chen’s lab collaborated on this research with pediatric neuro-oncologist <a href="http://pediatrics.wustl.edu/faculty/rubin_joshua_b">Joshua Rubin</a>, MD, PhD, professor of pediatrics at the School of Medicine who treats patients at St. Louis Children’s Hospital. Chen said the team hopes to translate the findings of this study into clinical trials for children with DIPG.</p><p>There are difficulties ahead, but Chen believes researchers will need to continue to innovate when it comes to solving such a difficult problem as treating DIPG.<br/></p><span><hr/></span><p>Dezhuang Ye, Xiaohui Zhang, Yimei Yue, RameshRaliya, Pratim Biswas, Sara Taylor, Yuan-chuan Tai, Joshua B.Rubin, Yongjian Liu, Hong Chen. <a href="https://www.sciencedirect.com/science/article/pii/S0168365918304140#!">Focused ultrasound combined with microbubble-mediated intranasal delivery of gold nanoclusters to the brain</a>. 28 September 2018;  <a href="http://doi.org/10.1016/j.jconrel.2018.07.020" rel="nofollow">doi.org/10.1016/j.jconrel.2018.07.020</a><a href="https://www.sciencedirect.com/science/article/pii/S0168365918304140#!" name="bau0050"></a></p><p>This work was supported by a grant from the American Cancer Society, grant number <a href="https://www.sciencedirect.com/science/article/pii/S0168365918304140#gts0005">IRG-58-010-61-1</a>. It was also supported by the Children’s Discovery Institute of Washington University and St. Louis Children’s Hospital, grant number <a href="https://www.sciencedirect.com/science/article/pii/S0168365918304140#gts0010">MC-II-2017-661</a>. Ramesh Raliya was partially supported by the CMMN Grant NIH-NCI <a href="https://www.sciencedirect.com/science/article/pii/S0168365918304140#gts0015">U54CA199092</a>. We thank Professor Rajiv Chopra and Chenchen Bing from the University of Texas Southwestern for providing us with the ultrasound <a title="Learn more about Transducer" href="https://www.sciencedirect.com/topics/materials-science/transducer">transducer</a> and technical assistance in setting up the second ultrasound system used in this study.</p><SPAN ID="__publishingReusableFragment"></SPAN><p><br/></p><p>​</p><span><div class="cstm-section"><h3>A targeted inspiration</h3><div> <strong></strong></div><div><div rtenodeid="190" style="text-align: center;"><img src="/Profiles/PublishingImages/Chen_Hong_7_15_06.jpg?RenditionID=3" alt="" style="margin: 5px;"/><br/></div><div><br/></div><div rtenodeid="182"><span class="ms-rteStyle-References">Hong Chen’s lab collaborated on this research with Joshua Rubin, MD, PhD, professor of pediatrics at the School of Medicine. And it all started with a couple of colleagues talking one day:</span></div><div rtenodeid="183"><br rtenodeid="184" class="ms-rteStyle-References"/></div><div rtenodeid="185"><span class="ms-rteStyle-References">“My work in this field started with a conversation with him,” Chen said. “He said, ‘Wow, this would be a perfect technique for treating this deadly disease.’ Without him to point me in this direction, I probably wouldn’t have known this application existed.<br rtenodeid="187"/></span></div><div rtenodeid="188"><br rtenodeid="189" class="ms-rteStyle-References"/></div><div><span class="ms-rteStyle-References">“That’s why I consider the Washington University environment, and the School of Engineering & Applied Science, so unique. It provides you so much opportunity to work with people from different backgrounds. It allowed me to expand my research scope and to be able to work on clinically relevant questions.”</span><br rtenodeid="193"/></div></div></div></span><p><br/></p>Brandie Jeffersonhttps://source.wustl.edu/2018/09/focused-delivery-for-brain-cancers/2018-09-04T05:00:00ZResearchers in engineering and medicine work toward a more focused drug delivery system that could target tumors lodged in the brainstem, the body’s most precious system.<p>​Interdisciplinary research brings together imaging, aerosols and pediatric neuro oncology to fight tumors<br/></p>Y
https://engineering.wustl.edu/news/Pages/Brain-Initiative-grants-Chen-2-point-7-million-for-neuroscience-study.aspx913Brain Initiative grants Chen $2.7 million for neuroscience study<p>​An interdisciplinary team of WashU researchers will be developing a non-invasive neuromodulation tool<br/></p><style type="text/css"> p.p1 {margin: 0.0px <span class="ms-rtegenerate-skip" style="white-space: nowrap;"><span class="ms-rtestate-read ms-rtegenerate-skip" contenteditable="false" style="font-size: 8pt;"><a class="ms-rtegenerate-skip"><img src="/_layouts/images/blank.gif" alt="Misspelled Word" class="ms-rtegenerate-skip" style="width: 0px;"></a></span><span id="rnd13651" class="ms-spellcheck-error ms-rtegenerate-skip">0.0px</span></span> <span class="ms-rtegenerate-skip" style="white-space: nowrap;"><span class="ms-rtestate-read ms-rtegenerate-skip" contenteditable="false" style="font-size: 8pt;"><a class="ms-rtegenerate-skip"><img src="/_layouts/images/blank.gif" alt="Misspelled Word" class="ms-rtegenerate-skip" style="width: 0px;"></a></span><span id="rnd48390" class="ms-spellcheck-error ms-rtegenerate-skip">0.0px</span></span> <span class="ms-rtegenerate-skip" style="white-space: nowrap;"><span class="ms-rtestate-read ms-rtegenerate-skip" contenteditable="false" style="font-size: 8pt;"><a class="ms-rtegenerate-skip"><img src="/_layouts/images/blank.gif" alt="Misspelled Word" class="ms-rtegenerate-skip" style="width: 0px;"></a></span><span id="rnd49410" class="ms-spellcheck-error ms-rtegenerate-skip">0.0px</span></span>; line-height: 18.0px; font: 16.0px 'Helvetica <span class="ms-rtegenerate-skip" style="white-space: nowrap;"><span class="ms-rtestate-read ms-rtegenerate-skip" contenteditable="false" style="font-size: 8pt;"><a class="ms-rtegenerate-skip"><img src="/_layouts/images/blank.gif" alt="Misspelled Word" class="ms-rtegenerate-skip" style="width: 0px;"></a></span><span id="rnd19043" class="ms-spellcheck-error ms-rtegenerate-skip">Neue</span></span>'; color: #222222; -<span class="ms-rtegenerate-skip" style="white-space: nowrap;"><span class="ms-rtestate-read ms-rtegenerate-skip" contenteditable="false" style="font-size: 8pt;"><a class="ms-rtegenerate-skip"><img src="/_layouts/images/blank.gif" alt="Misspelled Word" class="ms-rtegenerate-skip" style="width: 0px;"></a></span><span id="rnd5286" class="ms-spellcheck-error ms-rtegenerate-skip">webkit</span></span>-text-stroke: #222222; background-color: #<span class="ms-rtegenerate-skip" style="white-space: nowrap;"><span class="ms-rtestate-read ms-rtegenerate-skip" contenteditable="false" style="font-size: 8pt;"><a class="ms-rtegenerate-skip"><img src="/_layouts/images/blank.gif" alt="Misspelled Word" class="ms-rtegenerate-skip" style="width: 0px;"></a></span><span id="rnd19009" class="ms-spellcheck-error ms-rtegenerate-skip">ffffff</span></span>} span.s1 {font-kerning: none} </style><img alt="Hong Chen" src="/Profiles/PublishingImages/Chen_Hong_7_15_06.jpg?RenditionID=2" style="BORDER:0px solid;" /><p>​Hong Chen, assistant professor of biomedical engineering in the School of Engineering & Applied Science and radiation oncology in the School of Medicine, has received a <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=9583521&icde=40963129&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball=">$2.7 million grant</a> from the National Institutes of Health's Brain Initiative to develop a non-invasive neuromodulation tool that works on the cellular level and uses focused ultrasound, operating with high spatiotemporal precision. Chen is working across disciplines, with <a href="/Profiles/Pages/Jianmin-Cui.aspx">Jianmin Cui</a>, professor in biomedical engineering; <a href="https://www.mir.wustl.edu/research/research-laboratories/optical-radiology-laboratory-orl/people/joseph-culver">Joseph Culver</a>, professor of radiology, physics, and biomedical engineering at the School of Medicine; and former WashU faculty member Michael Bruchas, PhD.</p><p>Functional Optical Imaging Feedback-Controlled Cellular-Level Ultrasound Stimulation (FOCUS), will help researchers better understand the general underpinnings of neuroscience, but the group has also envisioned a pathway for clinical use. The project is part of the NIH's <a href="https://www.braininitiative.nih.gov/">BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative</a>, federally-funded research aimed at revolutionizing our understanding of the human brain. <br/></p>Hong ChenBrandie Jefferson2018-08-30T05:00:00ZAn interdisciplinary team of WashU researchers will be developing a non-invasive neuromodulation tool

​​​