The molecular and cellular networks that compose cells and tissues fundamentally determine the emergent properties that shape the physiology of healthy organs and pathological tissues that cause diseases, like neurodegeneration and cancer. Their complexity requires novel and integrated approaches that span scales, ideas, and techniques. Pushing the boundary of knowledge in the direction of understanding molecular, cellular, and tissue systems will allow us to gain the insight required to build better therapies.

This program seeks to develop innovative approaches for treating disease by manipulating molecules, cells or systems. For example, diseases associated with misfolded proteins, such as Alzheimer’s and Huntington’s, could be treated by understanding and eventually modifying how proteins fold into their complex three-dimensional, functional configurations. A better understanding of most biological processes is likely to depend upon system-wide approaches at all levels.

Primary Faculty

Jianmin Cui
Nathaniel Huebsch
Rohit Pappu
Barani Raman
Jai Rudra
Yoram Rudy
Jin-Yu Shao
Jonathan Silva
Michael Vahey

Affiliate Faculty

Ghazal Ashrafi
Randall Bateman
Philip Bayly
Matthew Bersi
Michael Brent
Barak Cohen
Meaghan Creed
David Curiel
Gautam Dantas
Daved Fremont
Anthony French
Michael Gach
Guy Genin
Michael Greenberg
Farshid Guilak
Edward Han
James Huettner
Meredith Jackrel
Jin-Moo Lee
Fangqiong Ling
Christopher Lingle
Christopher Maher
Audrey McAlinden
Gretchen Meyer
Jeffrey Milbrandt
Jeffrey Millman
Robi Mitra
Colin Nichols
Camillo Padoa-Schioppa
Hua Pan
Amit Pathak
Philip Payne
Zachary Pincus
David Piston
Maria Remedi
Patricia Ribeiro Pereira
Janice Robertson
Erica Scheller
Vijay Sharma
Monica Shokeen
Lilianna Solnica-Krezel
S. Joshua Swamidass
Tony Tsai
Pamela Woodard
Hani Zaher
Mohamed Zayed
Fuzhong Zhang